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West Virginia University Deflux Experience and the Utility Of An Intra-Operative Cystogram With A Simulated Voiding Phase
Adam E Perlmutter, William F. Tarry
West Virginia University, Morgantown, WV

Introduction: To report a single surgeon’s experience with injection of dextranomer hyaluronic acid (Deflux) for the treatment of vesicoureteral reflux and to assess the utility of intra-operative cystogram with a simulated voiding phase.
Methods: From September 2003 to June 2005, 24 children underwent injection of deflux for the treatment of vesicoureteral reflux (VUR). A total of 38 ureters were treated. After deflux injection, 14 patients had a cystogram with simulated voiding phase to assess for the presence of VUR. All patients were scheduled for a voiding cystourethrogram (VCUG) three months post-operatively to assess for persistent reflux. The surgery was considered a success only if patients did not demonstrate reflux on their post-operative VCUG.
Results: Of the 24 patients undergoing deflux injection, 14 had complete resolution of their VUR. Seven patients had persistent VUR and 3 patients were lost to follow-up. A total of 38 ureters were injected. Twenty-three ureters no longer refluxed, while 10 ureters continued to reflux and 5 ureteral units were lost to follow-up. Fourteen patients had an intra-operative cystogram with simulated voiding phase. The intra-operative cystogram with simulated voiding phase was negative in all patients except for one patient who demonstrated the presence of de novo contralateral VUR. There were 6 true negatives on intra-operative cystogram and 5 false negatives.
Conclusions: Our deflux results at West Virginia University compare well to the results reported by others in the literature. An intra-operative cystogram may demonstrate unsuspected contralateral reflux but appears not to predict success of deflux injections.


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